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You are here: Home > Arthritis Resource Center > Glucosamine

Arthritis Cure
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Glucosamine Research and Studies

Glucosamine works to stimulate joint function and repair. It is most effective in treating osteoarthritis, the most prevalent type of arthritis. A number of studies over the last 20 years have shown this. For example, a 1982 clinical study compared usage of the NSAID ibuprofen with glucosamine sulfate, for osteoarthritis of the knee. During the first two weeks, ibuprofen decreased pain faster, but by the fourth week the glucosamine group was well ahead in pain relief. The overall results showed 44% of the glucosamine group had pain relief compared to 15% for ibuprofen. Because glucosamine is not an anti-inflammatory drug, it takes longer to start working, but it works equally well.

Another 1982 open trial study with 252 doctors and 1,506 patients conducted in Portugal provided good clinical information on appropriate dosage and usage of glucosamine sulfate for osteoarthritis. For 50 days, patients took 500 mg of glucosamine sulfate three times a day. The results showed 95% of the patients benefited from the supplement, as it reduced their pain whether they were resting, standing, or exercising. This study also showed the effects of glucosamine on obese patients, however, they may require higher dosages to offset the joints' reaction to the stress from obesity Those patients also taking diuretics or suffering from peptic ulcers were also studied regarding the effect of, and their tolerance to, glucosamine. The former might require higher dosages and the latter need to take glucosamine with food.

In a more recent 2000 study at the Assaf Harofeh Medical Center, in Ziffrin, 57 patients with osteoarthritis in the knee were treated randomly for four weeks with glucosamine sulfate intravenously combined with an 800 mg of chondroitin sulfate daily, or with a placebo. As in the 1982 study, a record was kept of their knee pain when at rest, standing, or moving. No reduction of symptoms occurred with the placebo group, but the glucosamine/chondroitin sulfate group showed much reduction of symptoms in all activity/nonactivity functions. This latter group also showed no negative reactions or any change in their blood tests. The study concluded that glucosamine sulfate is safe for long-term osteoarthritis treatment.

Another osteoarthritis study of the knee, in 1999 at the University of Liege in Belgium, involved 212 patients worldwide. These patients were randomly given either glucosamine or a placebo for three years. The patients' pain was measured every four months and x rays were taken of their knees. The placebo group had more pain and narrowed joints, while the glucosamine group had no narrowing of joints and their condition improved. This was one of the first studies to show how glucosamine works by stopping the joints from narrowing. It was also the first long-term study conducted.

Since then, the University of Utah received a $6.6 million grant (September 1999) from the National Institutes of Health for another major ongoing glucosamine study.

Harvard Medical School conducted a somewhat unorthodox study where patients scheduled for hip surgery were given ground chicken bone supplements. After two weeks of taking these supplements, their pain was reduced considerably.


A leading glucosamne product is Syn-Flex®. Syn-Flex is a fast-acting, pharmaceutical-quality osteoarthritis supplement that works for humans and pets. Fomulated with pharmaceutical quality liquid glucosamine sulfate, glucosamine hydrochloride, chondroitin sulfate, and ten other synergistic ingredients, Syn-Flex® is will ease your pain quickly. Learn more about Syn-Flex® here.








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